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Synfacts 2009(3): 0344-0344  
DOI: 10.1055/s-0028-1087739
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Aldol Reaction with CA-POM under Neat and Aqueous Conditions

Contributor(s): Yasuhiro Uozumi, Noboru Kobayashi
J. Li, S. Hu, S. Luo*, J.-P. Cheng*
Institute of Chemistry, Chinese Academy of Science, Beijing and Nankai University, Tianjin, P. R. of China
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Chiral amine-polyoxometalate ­hybrid catalysts 3 (CA-POM hybrid) were prepared by treatment of a POM acid 1 with chiral amines 2 in dry tetrahydrofuran. CA-POM hybrid catalysts 3a and 3b promoted the aldol reaction of ketones and aldehydes to give the corresponding products (neat conditions: 1 mol% chiral amine, 25 examples, up to 99% yield and >99% ee; aqueous conditions: 1 or 5 mol% chiral amine, 20 examples, up to 90% yield and 98% ee).