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Synfacts 2009(3): 0297-0297  
DOI: 10.1055/s-0028-1087776
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Hydrogenation of Enamines to Access Chiral Tertiary Amines

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
P. Cheruku, T. L. Church, A. Trifonova, T. Wartmann, P. G. Andersson*
Uppsala University, Sweden
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Publikationsdatum:
19. Februar 2009 (online)

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Significance

Prior to this work several asymmetric transition-metal-catalyzed hydrogenation reactions using Ti, Rh, and Ir as metal sources have been investigated, providing chiral tertiary amines. In the present study, the authors utilized an iridium complex derived form N,P ligand L1. This system provides modest to good enantioselectivities for the hydrogenation of various acetophenone derived enamines.