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Synfacts 2009(3): 0256-0256  
DOI: 10.1055/s-0028-1087800
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Regiospecific Synthesis of 1,3-Diaryliso-benzofurans

Contributor(s): Victor Snieckus, Jignesh J. Patel
J. Jacq, C. Einhorn, J. Einhorn*
Université Joseph Fourier, Grenoble, France
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Publikationsdatum:
19. Februar 2009 (online)

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Significance

Described is the convenient, efficient regiospecific synthesis of functionalized 1,3-diarylisobenzofurans by chemoselective addition of arylmagnesium reagents to ortho-aroylbenz­aldehydes, which are obtained by an interesting lead tetraacetate oxidation-rearrangement of N-aroylhydrazones of substituted salicylaldehydes (A. Kotali, P. G. Tsoungas Tetrahedron Lett. 1987, 28, 4321).