Efficient Cobalt-Catalyzed Coupling of Aryl Grignard Reagents with Alkyl Bromides

Significance

An efficient cobalt-catalyzed cross-coupling reaction of aryl Grignard reagents with primary and secondary alkyl bromides is reported. The reaction proceeds rapidly under very mild conditions and tolerates many functional groups. A readily available cobalt catalyst is used in the process, which is in general more efficient and versatile than the similar iron-catalyzed sp^²-sp^³ cross-coupling reactions.