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Synfacts 2009(4): 0431-0431  
DOI: 10.1055/s-0028-1087835
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Hydroformylation of Homoallylic Azides: A Rapid Approach toward Alkaloids

Contributor(s): Paul Knochel, Andreas J. Wagner
T. Spangenberg, B. Breit*, A. Mann*
CNRS, Illkirch, France and Albert-Ludwigs-Universität Freiburg, Germany
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Publikationsdatum:
23. März 2009 (online)

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Significance

The authors report in this manuscript an unprecedented hydroformylation of homoallylic azides using syngas under rhodium/biphephos catalysis. The yields of the hydro-formylation are generally very good and the resulting azido-functionalized aldehydes are readily converted into alkaloid structures in one-pot sequences.