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Synfacts 2009(4): 0457-0457  
DOI: 10.1055/s-0028-1087858
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of 1,2,3-Triazole Derivatives with Copper Nanoparticles in Water

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
H. Sharghi*, R. Khalifeh, M. M. Doroodmand
Shiraz University, Iran
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Publikationsverlauf

Publikationsdatum:
23. März 2009 (online)

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Significance

Copper nanoparticles on charcoal (Cu/C) were prepared by oxidation of an activated carbon with HNO3, followed by the treatment with CuI in EtOH. The three-component reaction of halides 1, terminal alkynes 2, and sodium azide was carried out with 1 mol% Cu of Cu/C in H2O to give the corresponding 1,2,3-triazole derivatives 3 in 69-91% yield (19 examples).