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Synfacts 2009(4): 0395-0395  
DOI: 10.1055/s-0028-1087869
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Addition of Arylboronic Acids to N-Benzylisatin

Contributor(s): Hisashi Yamamoto, Pingfan Li
H. Lai, Z. Huang, Q. Wu, Y. Qin*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

The novel tetra-ortho-substituted biphenyl phosphinoimine ligands are synthesized by condensation of the corresponding aldehydes and enantiopure tert-butylsulfinamide, followed by separation of diastereomeric products. A difficult 1,2-addition reaction of arylboronic acids to N-benzylisatin is chosen to evaluate these new ligands via palladium catalysis.