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Synfacts 2009(4): 0407-0407  
DOI: 10.1055/s-0028-1087906
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Lewis Acid Catalyzed C-H Bond Functionalization/Hydride Transfer

Contributor(s): Mark Lautens, Praew Thansandote
K. M. McQuaid, D. Sames*
Columbia University, New York, USA
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Publikationsverlauf

Publikationsdatum:
23. März 2009 (online)

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Significance

The authors report a transition-metal free hydride transfer/cyclization reaction activated by Lewis acidic boron. A preliminary scope is reported with good yields and diastereoselectivities. Notably, a substrate derived from (-)-menthol provided a single diastereomer.