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Synfacts 2009(4): 0363-0363  
DOI: 10.1055/s-0028-1088083
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Cephalotaxine

Contributor(s): Philip Kocienski, Zofia Komsta
T. Taniguchi, H. Ishibashi*
Kanazawa University, Japan
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Publikationsdatum:
23. März 2009 (online)

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Significance

Cephalotaxine is a member of a class of cytotoxic alkaloids isolated from Asian plum yews. Certain ester derivatives of cephalotaxine show antileukemic activity. The focal step of this relatively concise synthesis is the construction of two rings via a radical cascade (F → G).