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Synfacts 2009(5): 0540-0540
DOI: 10.1055/s-0028-1088187
DOI: 10.1055/s-0028-1088187
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Thioethers from Aryl Halides via Palladium-Catalyzed C-S Cross-Coupling
M. A. Fernández-Rodríguez, J. F. Hartwig*
University of Illinois, Urbana, and Yale University, New Haven, USA
Further Information
Publication History
Publication Date:
22 April 2009 (online)
Significance
Complexes of palladium with the bisphosphine ligand CyPFt-Bu are reported to catalyze the C-S cross-coupling between bromo- or iodoarenes and free thiols in very good to excellent yields and without the formation of side products. The reaction has a broad substrate scope and tolerates a wide range of functional groups.