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Synfacts 2009(5): 0569-0569  
DOI: 10.1055/s-0029-1216551
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper/Aluminum Hydrotalcite Catalyzed O-Arylation of Phenols/Alcohols with Aryl Halides

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Hidetoshi Ohta
B. Sreedhar*, R. Arundhathi, M. A. Reddy, M. L. Kantam
Indian Institute of Chemical Technology, Hyderabad, India
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Copper/aluminum hydrotalcite (Cu/Al-HF, Cu:Al = 2.5:1, 34.94 atm% Cu) was found to catalyze O-arylation of various phenols and alcohols 2 with aryl halides 1. Thus, the reaction of 1 with 2 was carried out in the presence of Cu/Al-HF and K2CO3 in DMF to give the corresponding aryl ethers 3 in 47-97% yield. The Cu/Al-HF catalyst was recovered by filtration and reused four times with slight loss of catalytic activity.