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Synfacts 2009(5): 0573-0573  
DOI: 10.1055/s-0029-1216557
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A³ Coupling Reaction with Ni-MOF- Supported Silver Nanoparticles

Contributor(s): Yasuhiro Uozumi, Takao Osako
S. Wang, X. He, L. Song*, Z. Wang*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
22 April 2009 (online)

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Significance

Nickel metal-organic frameworks (Ni-MOF) supported silver nanoparticles were prepared by mixing silver nitrate and Ni-MOF, followed by treatment with urotropine (eq. 1). The nanoparticles catalyzed the A³ coupling of aldehydes, amines, and alkynes in MeCN to afford the corresponding propargylamines in 75-95% yield (eq. 2, 25 examples). In the coupling of formaldehyde, diethylamine, and phenylacetylene, the catalyst was recycled four times without significant loss of catalytic activity (4th recycling run: 93% yield).