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Synfacts 2009(5): 0537-0537
DOI: 10.1055/s-0029-1216586
DOI: 10.1055/s-0029-1216586
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Ruthenium-Catalyzed Asymmetric Hydrogenation of Aryl Ketones
Y. Li, K. Ding, C. A. Sandoval*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
22 April 2009 (online)
Significance
Ruthenium-based catalysts utilizing hybrid NH2-benzimidazole ligands were prepared and applied to the asymmetric hydrogenation of aryl ketones. The hydrogenations proceed in both protic and non-protic solvents and the product alcohols are obtained in high enantioselectivity, even with a substrate-to-catalyst ratio of 50000. In addition, the use of these ligands is reported to result in a reversal of the typically observed chiral induction.