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Synfacts 2009(5): 0526-0526
DOI: 10.1055/s-0029-1216596
DOI: 10.1055/s-0029-1216596
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Gold(I)-Catalyzed Intramolecular Cyclopropanation
I. D. G. Watson, S. Ritter, F. D. Toste*
University of California, Berkeley, USA
Further Information
Publication History
Publication Date:
22 April 2009 (online)
Significance
The synthesis of medium-sized rings is a formidable challenge in organic chemistry. Toward this end transition-metal-catalyzed intramolecular cyclopropanation via carbenoids has been applied. The authors report a gold(I)-catalyzed process for the asymmetric synthesis of seven- and eight-membered rings. The present work represents an advancement over existing methods of transition-metal-catalyzed intramolecular cyclopropanation and extends the authors previous work involving the transformations of gold(I) carbenoids.