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Synfacts 2009(5): 0531-0531
DOI: 10.1055/s-0029-1216619
DOI: 10.1055/s-0029-1216619
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective Friedel-Crafts Alkylation of Indoles with Alkylidene Malonates
Y. Liu, D. Shang, X. Zhou, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
The synthesis of optically active indole derivatives is important for the construction of more elaborate naturally occurring and potentially pharmaceutical agents. Most reports on the Friedel-Crafts alkylation of indoles with malonates are copper-catalyzed. The authors found a scandium catalyst with a chiral N,N′-dioxide ligand effective for this transformation.