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Synfacts 2009(5): 0516-0516
DOI: 10.1055/s-0029-1216625
DOI: 10.1055/s-0029-1216625
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Catalytic atropo-Enantioselective Ring Opening of Biaryl Lactones
T. Ashizawa, T. Yamada*
Keio University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. April 2009 (online)
Significance
In this paper, an AgBF4-phosphine complex was demonstrated to be an effective catalyst for the atropo-enantioselective ring opening of equilibrated enantiomer mixtures of biaryl lactones. Good yields and enantioselectivities for various substrates were achieved. Bulky tertiary amines were shown to be effective, even necessary in some cases, in promoting this transformation.