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Synfacts 2009(6): 0592-0592  
DOI: 10.1055/s-0029-1216672
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of BYK 405879

Contributor(s): Philip Kocienski
A. M. Palmer*, M. Webel*, C. Scheufler, D. Haag, B. Müller
NYCOMED GmbH, Konstanz and Singen, Germany
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Publikationsdatum:
25. Mai 2009 (online)

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Erratum zu diesem Artikel:

Synthesis of BYK 405879Synfacts 2009; 2009(09): 1058-1058
DOI: 10.1055/s-0029-1217795

Significance

The target molecule is a reversible inhibitor of the gastric proton pump enzyme and is being developed for the treatment of gastroeso­phageal reflux disease. The key step, a Noyori asymmetric transfer hydrogenation, required development of a special catalyst L.