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Synfacts 2009(6): 0693-0693  
DOI: 10.1055/s-0029-1216757
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

S-Arylation with Copper Nanoparticles under Microwave Conditions

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
C. Gonzalez-Arellano, R. Luque*, D. J. Macquarrie
The University of York, UK
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Publikationsdatum:
25. Mai 2009 (online)

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Significance

Hexagonal microporous silica-supported copper nanoparticles (Cu-HMS) were obtained by the reaction of CuCl2 with n-dodecyl­amine and tetraethoxyorthosilicate in a mixture of water and acetonitrile under microwave (200 W) ­irradiation for 1-15 minutes. The S-arylation of ­thiols with aryl iodides was carried out in the ­presence of Cu-HMS for 10-30 minutes under ­microwave irradiation to give the corresponding coupling products in up to >99% conversion with good selectivity.