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Synfacts 2009(6): 0691-0691  
DOI: 10.1055/s-0029-1216760
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazoles with PDAIS

Contributor(s): Yasuhiro Uozumi, Yoshikazu Yamamoto
A. Kumar*, R. A. Maurya, P. Ahmad
Central Drug Research Institute, Lucknow, India
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Publikationsdatum:
25. Mai 2009 (online)

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Significance

A polymer-supported hypervalent iodine reagent, poly[4-diacetoxyiodo]styrene (PDAIS), was used for the synthesis of benzimi-d­azoles, benzoxazoles and benzothiazoles. Thus, the coupling reaction of anilines 1 with aldehydes 2 in the presence of PDAIS gave the corresponding heterocyclic products 3 in up to 85% yield ­(29 examples). Various substituted anilines 1 were tolerated for the reaction.