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Synfacts 2009(7): 0807-0807  
DOI: 10.1055/s-0029-1217224
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Click Reaction Catalyzed by Copper-Supported Ionic Liquid Catalyst

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Toshihiro Watanabe
H. Hagiwara*, H. Sasaki, T. Hoshi, T. Suzuki
Niigata University, Japan
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Copper-supported ionic liquid catalyst (Cu-SILC) was prepared on the amorphous silica gel upon exposure to an MeCN solution of CuBr˙Me2S and [bmim]PF6. Huisgen [3+2] cyclo-addition of various azides 1 and terminal acetylenes 2 was carried out with Cu-SILC in 50% aqueous ethanol at room temperature to give the corresponding 1,4-disubstituted 1,2,3-triazoles 3a-l in 73-100% yield (12 examples).