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Synfacts 2009(7): 0811-0811
DOI: 10.1055/s-0029-1217226
DOI: 10.1055/s-0029-1217226
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Addition of Nucleophiles to Ketones with Polymer-Supported Sulfonamide
V. J. Forrat, D. J. Ramón*, M. Yus*
Universidad de Alicante, Spain
Further Information
Publication History
Publication Date:
22 June 2009 (online)
Significance
Polymer-supported chiral disulfon-amide 3 was prepared by mixing of compound 1 and polymer 2 in the presence of AIBN in THF. The polymer-supported chiral disulfonamide 3 assisted the enantioselective ethylation of ketones with Et2Zn in the presence of Ti(Oi-Pr)4 to give the corresponding products (29-94% yield, up to >99% ee).