Synthesis of Trichodermamide B

X. Wan; M. M. Joullié

doi:10.1055/s-0029-1217250

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2009(7): 0710-0710
DOI: 10.1055/s-0029-1217250

Synthesis of Natural Products and Potential Drugs

Synthesis of Trichodermamide B

Contributor(s): Philip Kocienski, Stewart Eccles
X. Wan, M. M. Joullié*
University of Pennsylvania, Philadelphia, USA

Further Information

Publication History

Publication Date:
22 June 2009 (online)

Permissions and Reprints

Significance

Both trichodermamides A and B were isolated from the marine-derived fungus Trichoderma virens. Trichodermamide B possesses cytotoxic activity with an IC₅₀ of 0.32 µg/mL against HCT-116 colon carcinoma. The molecule contains a rare oxazine ring system.