Iridium-Catalyzed C-H Arylation of Heteroarenes with Iodoarenes

Significance

Crabtree’s catalyst, [Ir(cod)(py)PCy₃]PF₆, is reported to catalyze the C-H arylation of various sulfur, nitrogen or oxygen heterocycles with aromatic iodides in the stoichiometric presence of Ag₂CO₃. The reaction tolerates functional groups such as nitro, ester, and cyano and yields the unsymmetrical heterobiaryl compounds in good to excellent yields. Additionally, using heteroarenes, bearing two acidic C-H bonds or diiodoarenes, triaryl products are afforded in good to very good yields.