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Synfacts 2009(7): 0778-0778  
DOI: 10.1055/s-0029-1217259
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Amination of Aryl Halides with Ammonia

Contributor(s): Paul Knochel, Andreas J. Wagner
T. Schulz, C. Torborg, S. Enthaler, B. Schäffner, A. Dumrath, A. Spannenberg, H. Neumann, A. Börner, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany
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Publikationsdatum:
22. Juni 2009 (online)

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Significance

The authors report herein a new protocol for the synthesis of substituted primary aromatic amines by using a solution of ammonia in dioxane in the presence of a palladium catalyst. Using the biaryl phosphine ligands 1 and 2, a variety of aromatic and heteroaromatic chlorides or bromides are converted into the respective amines in good to excellent yields tolerating a range of functional groups.