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Synfacts 2009(7): 0781-0781  
DOI: 10.1055/s-0029-1217265
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Intermolecular Hydroamination of Terminal Alkenes Using Gold(I) Catalysts

Contributor(s): Paul Knochel, Tobias Thaler
Z. Zhang, S. D. Lee, R. A. Widenhoefer*
Duke University, Durham, USA
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

A gold(I)-catalyzed intermolecular hydroamination of ethylene and unactivated al­kenes with cyclic ureas and carbamates was developed. The reaction proceeds with Markovnikov regioselectivity and shows a broad tolerance of functional groups.