Synthesis of Substituted Dienes through Isomerization of Allenamides

Significance

The authors report a regioselective rearrangement of allenamides yielding dienes bearing amido groups. Although allenes are known to undergo such isomerizations, the authors demonstrate an application to the stereo­selective synthesis of products which are difficult to obtain through other means. The yields observed are good for a range of substituted analogues and the regioselectivity achieved is excellent.