Synthesis of Chiral Biaryl Compounds Through Cycloisomerization

Significance

Biaryl motifs possessing axial chirality are common in biologically active compounds and are often utilized in chiral ligands. The use of cycloadditions and cycloisomerizations to access such structures has been explored more recently. The authors report a palladium-catalyzed version of this reaction constructing 4-aryl-2-pyridones (2) in good yields and selectivities.