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Synfacts 2009(7): 0722-0722  
DOI: 10.1055/s-0029-1217312
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Synthesis of 2-Substituted Oxazolopyridines

Contributor(s): Victor Snieckus, Johnathan Board
D. Xu, X. Xu, Z. Liu, L.-P. Sun*, Q. You
China Pharmaceutical University, Nanjing and Sun Yat-sen University, Guangzhou, P. R. of China
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Publication History

Publication Date:
22 June 2009 (online)

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Significance

Reported is the synthesis of oxa­zolo[5,4-b]pyridines and oxazolo[4,5-b]pyridines by copper-catalyzed intramolecular C-O coupling reactions. The substrate scope was reasonably well examined and appears to be general for R¹, R² = Ar substituents. However, low yields of products were obtained when R¹, R² = Et or 2-pyridyl substitution was attempted.