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Synfacts 2009(8): 0907-0907  
DOI: 10.1055/s-0029-1217490
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Ynamides via Coupling of 1,1-Dibromo-1-alkenes with Amides

Contributor(s): Paul Knochel, Tobias Thaler
A. Coste, G. Karthikeyan, F. Couty, G. Evano*
Université de Versailles Saint-Quentin en Yvelines, Versailles, France
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

A general and selective copper(I)-mediated synthesis of ynamides is presented. The reaction tolerates sensitive functional groups, such as aromatic chlorides and nitro groups, and was found to be applicable to the functionalization of complex amides.