Synthesis of (+)-11-Hydroxyerythratidine

T. Onoda; Y. Takikawa; T. Fujimoto; Y. Yasui; K. Suzuki; T. Matsumoto

doi:10.1055/s-0029-1217608

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Synfacts 2009(9): 0948-0948
DOI: 10.1055/s-0029-1217608

Synthesis of Natural Products and Potential Drugs

Synthesis of (+)-11-Hydroxyerythratidine

Contributor(s): Philip Kocienski
T. Onoda, Y. Takikawa, T. Fujimoto, Y. Yasui, K. Suzuki, T. Matsumoto*
Tokyo Institute of Technology and SORST-JST Agency, Japan

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Publication History

Publication Date:
21 August 2009 (online)

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Significance

The first synthesis of 11-hydroxyerythratidine features the highly diastereoselec-tive construction of the spirocenter in D using a Cu(OTf)₂-promoted cyclization of the ortho-quinone acetal C.