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Synfacts 2009(9): 0996-0996  
DOI: 10.1055/s-0029-1217625
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Addition of Terminal Alkynes to Imines Catalyzed by Copper(I)

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
J. Wang, Z. Shao, K. D. W. Y. Yu*, A. S. C. Chan*
The Hong Kong Polytechnic University, P. R. of China
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Publication History

Publication Date:
21 August 2009 (online)

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Significance

The authors have developed the first catalytic asymmetric addition of terminal alkynes to β-imino esters. The corresponding β-amino esters were obtained in excellent yields and good enantioselectivities. Furthermore, the β-imino esters were easily prepared by means of a modified Reformatsky reaction (see Scheme).