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Synfacts 2009(9): 1045-1045  
DOI: 10.1055/s-0029-1217660
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Optical Resolution with Immobilized Enzymes on Nanoparticles

Contributor(s): Yasuhiro Uozumi, Yoshikazu Yamamoto
K. S. Lee, M. H. Woo, H. S. Kim, E. Y. Lee*, I. S. Lee*
Kyung Hee University, Gyeonggi-do and Kyungsung University, Busan, Republic of Korea
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Publication History

Publication Date:
21 August 2009 (online)

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Significance

Enzyme-anchored hybrid nanoparticles (HIS-HNP) were prepared by reaction of His-tagged enzymes (epoxide hydrases) with the PEG-HNP-bearing NiO particles (eq. 1). The kinetic resolution of racemic styrene oxide was performed with HIS-HNP to give enantioenriched (S)-styrene oxide (>98% ee). The catalyst was magnetically separated from the reaction mixture and reused five times (eq. 2).