Ruthenium-Catalyzed Oxidation of Primary Alcohols into Amides

A. J. A. Watson; A. C. Maxwell; J. M. J. Williams

doi:10.1055/s-0029-1217697

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Synfacts 2009(9): 1026-1026
DOI: 10.1055/s-0029-1217697

Metal-Mediated Synthesis

Ruthenium-Catalyzed Oxidation of Primary Alcohols into Amides

Contributor(s): Paul Knochel, Andreas J. Wagner
A. J. A. Watson, A. C. Maxwell, J. M. J. Williams*
University of Bath and GlaxoSmithKline Research and Development, Stevenage, UK

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Publication History

Publication Date:
21 August 2009 (online)

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Significance

Commercially available [Ru(4-cymene)Cl₂]₂ in combination with bis(diphenyl-phosphino)butane (dppb) is shown to catalyze the oxidative coupling of primary alcohols with primary amines affording secondary amides in good yields.