Synthesis of Diarylmethanes via Pd-Catalyzed α-Arylation
of Benzylketones

J. R. Schmink; N. E. Leadbeater

doi:10.1055/s-0029-1217762

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Synfacts 2009(9): 1025-1025
DOI: 10.1055/s-0029-1217762

Metal-Mediated Synthesis

Synthesis of Diarylmethanes via Pd-Catalyzed α-Arylation of Benzylketones

Contributor(s): Paul Knochel, Tobias Thaler
J. R. Schmink, N. E. Leadbeater*
University of Connecticut, Storrs, USA

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Publication History

Publication Date:
21 August 2009 (online)

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Significance

A novel straightforward synthesis of diarylmethanes using ligand-free PdCl₂ has been developed. This microwave-based procedure can be applied to electron-poor and electron-rich benzyl ketones and aryl/vinyl bromides.