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Synfacts 2009(10): 1070-1070  
DOI: 10.1055/s-0029-1217863
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Lemonomycinone Amide

Contributor(s): Philipp Kocienski, Stewart Eccles
Y.-C. Wu, G. Bernadat, G. Masson, C. Couturier, T. Schlama, J. Zhu*
Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette and Centre de Recherches et de Technologie de Lyon, Saint Fons, France
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Publikationsdatum:
22. September 2009 (online)

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Significance

Lemonomycin was isolated from the fermentation broth of Streptomyces candidas and has strong activity against several bacterial strains including MRSA. Noteworthy is the phase-transfer-catalyzed enantioselective alkylation of B and the intramolecular Mannich reaction to give J.