Synthesis of an S1P1 Agonist

doi:10.1055/s-0029-1217868

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Synfacts 2009(10): 1061-1061
DOI: 10.1055/s-0029-1217868

Synthesis of Natural Products and Potential Drugs

Synthesis of an S1P₁ Agonist

Contributor(s): Philip Kocienski
S. R. Fix-Stenzel, M. E. Hayes*, X. Zhang, G. A. Wallace, P. Grongsaard, L. M. Schaffter, S. M. Hannick, T. S. Franczyk, R. H. Stoffel, K. P. Cusack
Abbott Laboratories, Abbott Park and Abbott Research Center, Worcester, USA

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Publikationsdatum:
22. September 2009 (online)

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Significance

The sphingosine-1-phosphate (S1P₁) receptor is involved in the sequestration of lymphocytes into secondary organs thereby preventing them from causing an autoimmune response. Agonism of the S1P₁ receptor may offer a treatment for multiple sclerosis. The target molecule induces lymphocyte sequestration in mice.