Suzuki-Miyaura and Stille Coupling Reactions with Pd(0)-MCM-41 Catalyst

Significance

A mesoporous silica-supported palladium(0) complex [Pd(0)-MCM-41] catalyzed the Suzuki-Miyaura cross-coupling reaction of aryl halides with phenylboronic acid to give the corresponding biaryls in 24-97% yield (6 examples, eq. 1). The Stille cross-coupling reactions of aryl halides with phenyl tributylstannane also proceeded with Pd(0)-MCM-41 to give the corresponding biaryls in 32-99% yield (6 examples, eq. 2). The catalyst was recovered by centrifugation and reused three times without loss of catalytic activity for both Suzuki-Miyaura (1^st-4^th runs: 90-95%) and Stille (1^st-4^th runs: 68-72%) cross-coupling reactions of iodobenzene.