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Synfacts 2009(10): 1167-1167  
DOI: 10.1055/s-0029-1217876
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Hydration of Nitriles to Amides with Supported Silver Nanoparticles

Contributor(s): Yasuhiro Uozumi, Takao Osako
T. Mitsudome, Y. Mikami, H. Mori, S. Arita, T. Mizugaki, K. Jitsukawa, K. Kaneda*
Osaka University, Japan
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Hydroxyapatite-supported silver nanoparticles (AgHAP) catalyzed the hydration of various nitriles in water at 140-180 ˚C to give the corresponding amides in up to 99% yield (23 examples). In the hydration of pyrazinecarbonitrile, the catalyst was readily separated by centrifugation and reused four times without significant loss of catalytic activity.