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Synfacts 2009(10): 1149-1149  
DOI: 10.1055/s-0029-1217886
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Naphthalenes via Gold(III)-Catalyzed Addition of Aryl Alkynes to Ketones

Contributor(s): Paul Knochel, Andrei Gavryushin
R. Balamurugan*, V. Gudla
University of Hyderabad, India
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Publikationsverlauf

Publikationsdatum:
22. September 2009 (online)

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Significance

Regioselective formation of polysubstituted naphthalenes is an important and challenging synthetic task. Reaction of benzylic carbonyl compounds with aryl alkynes under soft Lewis acid catalysis affords a variety of polysubstituted naphthalenes in good yields. This reaction can be quite useful for the preparation of fused polyarenes.