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Synfacts 2009(10): 1145-1145  
DOI: 10.1055/s-0029-1217889
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd(0)/Cu(I)-Mediated Cross-Coupling of Cyclic Thioamides and Thioureas

Contributor(s): Paul Knochel, Andrei Gavryushin
N. Arshad, J. Hashim, C. O. Kappe*
Karl-Franzens-University Graz, Austria
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Cyclic thioamides and thioureas are relatively easy to synthesize and are therefore useful starting materials for the synthesis of various heterocyclic derivatives. Herein, a general palladium-catalyzed cross-coupling of these compounds with various boron, tin, and silicon nucleophiles is described. The reaction can be applied to a various range of heterocyclic structures and proceeds in good yields.