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Synfacts 2009(10): 1144-1144
DOI: 10.1055/s-0029-1217890
DOI: 10.1055/s-0029-1217890
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper(I)-Catalyzed Efficient Arylation of Alcohols with Aryl Bromides
J. Niu, P. Guo, J. Kang, Z. Li, J. Xu*, S. Hu*
Changchun Institute of Applied Chemistry, Graduate School of Chinese Academy, Changchun, P. R. of China and Institute for Diabetes Discovery, Branford, USA
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
An efficient copper(I)-catalyzed arylation of alcohols with aryl bromides can be performed using readily available 8-hydroxyquinoline as a ligand and K3PO4 as a base. The reaction proceeds both in intramolecular and intermolecular way with a variety of aromatic and heterocyclic bromides giving good to excellent yields of aryl ethers.