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Synfacts 2009(10): 1144-1144  
DOI: 10.1055/s-0029-1217890
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(I)-Catalyzed Efficient Arylation of Alcohols with Aryl Bromides

Contributor(s): Paul Knochel, Andrei Gavryushin
J. Niu, P. Guo, J. Kang, Z. Li, J. Xu*, S. Hu*
Changchun Institute of Applied Chemistry, Graduate School of Chinese Academy, Changchun, P. R. of China and Institute for Diabetes Discovery, Branford, USA
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Publikationsdatum:
22. September 2009 (online)

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Significance

An efficient copper(I)-catalyzed ­arylation of alcohols with aryl bromides can be performed using readily available 8-hydroxyquinoline as a ligand and K3PO4 as a base. The reaction proceeds both in intramolecular and intermolecular way with a variety of aromatic and heterocyclic bromides giving good to excellent yields of aryl ethers.