Pd-Catalyzed Kinetic Resolution of 1-Alkyl-2-methylenecyclopropanes

Significance

Racemic 1-alkyl-2-methylenecyclopropanes undergo silaborative C-C bond cleavage kinetic resolution catalyzed by a palladium complex bearing a chiral phosphoramidite. Interaction of the double bond with palldium species favor the less hindered face of the olefin, therefore different vinylic C-C bonds are cleaved in the two enantiomers.