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Synfacts 2010(2): 0131-0131
DOI: 10.1055/s-0029-1219022
DOI: 10.1055/s-0029-1219022
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Alkaloid (±)-G. B. 13
K. K. Larson, R. Sarpong*
University of California, Berkeley, USA
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219022-1.jpg)
Significance
G. B. 13 is one of the 28 Galbulimima alkaloids isolated from a tree in Papua New Guinea. Some members of the family (e.g. himbacine) have potentially useful biological activity. The key step in the synthesis depicted is an unprecedented intramolecular rhodium(I)-catalyzed hydroarylation reaction (H → I).