Synthesis of Plaunotol

Y. Hirata; T. Yukawa; N. Kashihara; Y. Nakao; T. Hiyama

doi:10.1055/s-0029-1219034

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Synfacts 2010(2): 0130-0130
DOI: 10.1055/s-0029-1219034

Synthesis of Natural Products and Potential Drugs

Synthesis of Plaunotol

Contributor(s): Philip Kocienski
Y. Hirata, T. Yukawa, N. Kashihara, Y. Nakao*, T. Hiyama*
Kyoto University, Japan

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Publication History

Publication Date:
21 January 2010 (online)

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Significance

A detailed study of the scope of the nickel-catalyzed carbocyanation of alkynes with allyl cyanides culminated in the synthesis of plaunotol, a natural product active against Helicobacter pylori.