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Synfacts 2010(2): 0243-0243
DOI: 10.1055/s-0029-1219052
DOI: 10.1055/s-0029-1219052
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
One-Pot Synthesis of Indoles and Anilines with Supported Gold Nanoparticles
Y. Yamane, X. Liu, A. Hamasaki, T. Ishida, M. Haruta, T. Yokoyama, M. Tokunaga*
Kyushu University, Fukuoka, Tokyo Metropolitan University and Japan Science and Technology Cooperation, Kawaguchi, Japan
Further Information
Publication History
Publication Date:
21 January 2010 (online)
Significance
Gold nanoparticles supported on Fe2O3 (Au/Fe2O3) catalyzed the one-pot sequence of hydrogenation-hydroamination of (2-nitroaryl)-alkynes in toluene under H2 to give the corresponding indoles in up to 94% yield (eq. 1, 10 examples). The one-pot reductive amination of aldehydes with nitroarenes also proceeded in the presence of Au/Fe2O3 under H2 to afford the corresponding arylamines in up to 96% yield (eq. 2, 6 examples).