A Mild and Efficient Method for the Reduction of Nitriles

S. Laval; W. Dayoub; A. Favre-Reguillon; M. Berthod; P. Demonchaux; G. Mignani; M. Lemaire

doi:10.1055/s-0029-1219065

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Synfacts 2010(2): 0221-0221
DOI: 10.1055/s-0029-1219065

Metal-Mediated Synthesis

A Mild and Efficient Method for the Reduction of Nitriles

Contributor(s): Paul Knochel, Andreas J. Wagner
S. Laval, W. Dayoub, A. Favre-Reguillon, M. Berthod, P. Demonchaux, G. Mignani, M. Lemaire*
Université Lyon 1, Villeurbanne, Conservatoire National des Arts et Métiers, Paris, Minakem SAS, Beuvry-la-Forêt and Rhodia, Saint-Fons, France

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Publikationsdatum:
21. Januar 2010 (online)

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Significance

A simple and useful method for the reduction of nitriles into the corresponding amines is reported using tetramethyldisiloxane and titanium isopropoxide as reducing system. The primary amines are obtained as hydrochlorides and can be isolated in almost quantitative yield.