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Synfacts 2010(2): 0159-0159
DOI: 10.1055/s-0029-1219114
DOI: 10.1055/s-0029-1219114
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Multicomponent Synthesis of Trisubstituted Imidazoles
M. Adib*, S. Ansari, S. Feizi, J. A. Damavandi, P. Mirzaei
University of Tehran, Teacher Training University, Tehran and Shahid Beheshti University, Tehran, Iran
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219114-1.jpg)
Significance
Reported is the four-component synthesis of trisubstituted imidazoles involving the reaction of benzaldehydes, 2-bromoacetophenones, primary amines, and ammonium acetate. The reaction uses no added solvents and proceeds efficiently in short reaction times. A number of potential mechanisms are possible, one of which is shown by the authors. This example mechanism effectively demonstrates one of the main advantages of multicomponent reactions; the formation and use of reactive intermediates that would not usually be possible to access or isolate.
Book: M. R. Grimmett, In Science of Synthesis, Vol. 12; R. Neier, Ed.; Georg Thieme Verlag: Stuttgart, New York, 2002, 325-528.