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Synfacts 2010(2): 0228-0228
DOI: 10.1055/s-0029-1219127
DOI: 10.1055/s-0029-1219127
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Phosphite Addition to Nitroalkenes Using Squaramide Catalysis
Y. Zhu, J. P. Malerich, V. H. Rawal*
The University of Chicago, USA
Further Information
Publication History
Publication Date:
21 January 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219127-1.jpg)
Significance
Having recently introduced the squaramide motif in hydrogen-bonding catalysis (J. Am. Chem. Soc. 2008, 130, 14416), Rawal and colleagues now demonstrate its high efficiency in the Michael addition of diphenyl phosphite to nitroalkenes. Excellent enantiomeric induction and yields were observed for a range of nitroalkene substrates. Aliphatic and aromatic nitroalkenes were found to be equally suitable substrates.