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Synfacts 2010(2): 0232-0232
DOI: 10.1055/s-0029-1219139
DOI: 10.1055/s-0029-1219139
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
C 1-Symmetric Chiral Ammonium Betaine Catalyzed Mannich-Type Reaction
D. Uraguchi, K. Koshimoto, T. Ooi*
Nagoya University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Januar 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201002/lookinside/thumbnails/10.1055-s-0029-1219139-1.jpg)
Significance
C 1-Symmetric chiral quaternary ammonium betaines have been prepared and used as bifunctional organic catalysts. With catalyst 1 a highly stereoselective Mannich-type reaction of 2-alkoxythiazol-5(4H)-ones 3 with Boc-protected imines 2 has been achieved. The synthetic utility of products 4 was demonstrated by their conversion to different α,β-diamino acid derivatives.